A diagnosis of Alzheimer’s disease (AD), sadly, has become a rite of passage in so-called developed countries. AD is considered the most common form of dementia, which is defined as a serious loss of cognitive function in previously unimpaired persons, beyond what is expected from normal aging.
A 2006 study estimated that 26 million people throughout the world suffer from this condition, and that by 2050, the prevalence will quadruple, by which time 1 in 85 persons worldwide will be afflicted with the disease.
Given the global extent of the problem, interest in safe and effective preventive and therapeutic interventions within the conventional medical and alternative professions alike are growing.
Unfortunately, conventional drug-based approaches amount to declaring chemical war upon the problem, a mistake which we have documented elsewhere, and which can result in serious neurological harm, as evidenced by the fact that this drug class carries an alarmingly high risk for seizures, according to World Health Organization post-marketing surveillance statistics.
What the general public is therefore growing most responsive to is using time-tested, safe, natural and otherwise more effective therapies that rely on foods, spices and familiar culinary ingredients.
Remarkable Recoveries Reported after Administration of Turmeric
Late last year, a remarkable study was published in the journal Ayu titiled “Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia.” [ii] Researchers described three patients with Alzheimer’s disease whose behavioral symptoms were “improved remarkably” as a result of consuming 764 milligram of turmeric (curcumin 100 mg/day) for 12 weeks. According to the study:
All three patients exhibited irritability, agitation, anxiety, and apathy, two patients suffer from urinary incontinence and wonderings. They were prescribed turmeric powder capsules and started recovering from these symptoms without any adverse reaction in the clinical symptom and laboratory data.
After only 3 months of treatment, both the patients’ symptoms and the burden on their caregivers were significantly decreased.
The report describes the improvements thusly:
In one case, the Mini-Mental State Examination (MMSE) score was up five points, from 12/30 to 17/30. In the other two cases, no significant change was seen in the MMSE; however, they came to recognize their family within 1 year treatment. All cases have been taking turmeric for more than 1 year, re-exacerbation of BPSD was not seen.
This study illustrates just how powerful a simple natural intervention using a time-tested culinary herb can be. Given that turmeric has been used medicinally and as a culinary ingredient for over 5,000 years in Indian culture, even attaining the status of a ‘Golden Goddess,’ we should not be surprised at this result. Indeed, epidemiological studies of Indian populations reveal that they have a remarkably lower prevalence of Alzheimer’s disease relative to Western nations,  and this is true for both rural and more “Westernized” urban areas of India.
Could turmeric be a major reason for this?
Turmeric’s Anti-Alzheimer’s Properties
The GreenMedInfo.com database now contains a broad range of published studies on the value of turmeric, and its primary polyphenol curcumin (which gives it its golden hue), for Alzheimer’s disease prevention and treatment.*
While there are 114 studies on our Turmeric research page indicating turmeric has a neuroprotective set of physiological actions,  30 of these studies are directly connected to turmeric’s anti-Alzheimer’s disease properties.**
Two of these studies are particularly promising, as they reveal that curcumin is capable of enhancing the clearance of the pathological amyloid–beta plaque in Alzheimer’s disease patients, and that in combination with vitamin D3 the neurorestorative process is further enhanced. Additional preclinical research indicates curcumin (and its analogs) has inhibitory and protective effects against Alzheimer’s disease associated β-amyloid proteins.
Other documented Anti-Alzheimer’s mechanisms include:
Anti-inflammatory: Curcumin has been found to play a protective role against β-amyloid protein associated inflammation.
Anti-oxidative: Curcumin may reduce damage via antioxidant properties.
Anti-cytotoxic: Curcumin appears to protect against the cell-damaging effects of β-amyloid proteins.
Anti-amyloidogenic: Turmeric contains a variety of compounds (curcumin, tetrahydrocurcumin, demethoxycurcumin and bisdemethoxycurcumin) which may strike to the root pathological cause of Alzheimer’s disease by preventing β-amyloid protein formation.
Neurorestorative: Curcuminoids appear to rescue long-term potentiation (an indication of functional memory) impaired by amyloid peptide, and may reverse physiological damage by restoring distorted neurites and disrupting existing plaques.
Metal-chelating properties: Curcumin has a higher binding affinity for iron and copper rather than zinc, which may contribute to its protective effect in Alzheimer’s disease, as iron-mediated damage may play a pathological role.